Events

More than 900 specialists including gastroenterologists, hepatologists, oncologists and general practitioners were registered at the Forum.

Solagran Son took part in the work of the exhibition held at the Forum and in its scientific program.

The 13th International Baltic Scientific Medical Forum “Saint-Petersburg – Gastro2011” took place in the hotel Holiday Inn “Moscow Triumphal Gate” 18-20 May 2011.  

Almost 2000 specialists of more than 80 home and foreign companies from all regions of Russia, Belorussia, Ukraine, and the other countries of CIS, Baltic states and East Europe participated in the work of the Forum.

At the Forum Professor O. Minushkin made a report “The Use of Polyprenols: Ropren in the Treatment of Patients with Alcoholic Cirrhosis” 
FAQ
Hot Line
+7 (3822) 701-646
(from 9 a.m. to 4 p.m.
Moscow time)
Search

16.06.2010 | Clinical use of polyprenol preparation derived from green needles of spruce Picea Abies (L.) Karst in patients with dementia of the Alzheimers type and vascular cerebral affection

© V. S. Soultanov 1, V.I. Roshchin2, V.G. Agishev 3, I.S. Monakhova 3, K. P. Kulikov 3, T. V. Nikitina 4
1 Solagran Limited, Melbourne, Australia
2 Kirov Forest Technical Academy, Saint-Petersburg
3 Skvortsov-Stepanov Psychiatric Hospital, Saint -Petersburg
4 Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences, Saint -Petersburg
 
Introduction. The Alzheimer’s disease is the root cause for senile dementia of middle-aged and elderly people in developed countries. As human civilization grows older and duration of life increases the Alzheimer’s disease  is becoming a serious problem.  The regulation of acetylcholine level is supposed to be done by by butyrylcholin esterase BTL, the presence of which was revealed in senile plaques, fibrillar glomerules and vascular walls (amyloid angiopathy) along with acetylcholinesterase enzyme, the deficit of which is observed in Alzheimer’s disease. The deficit of adrenergic impulses in Alzheimer’s disease directly correlates with development and manifestation of depression that leads to three-times increase of monoamine oxidase (MAO).
 
 
For reasons given the world medical community is in search of a double –acting preparation – inhibitors of acetylcholinesterase and BCHE, and also inhibitors of acetylcholinesterase and MAO for treatment of Alzheimer’s disease. Search of new pharmaceuticals with minimum side effects is an actual problem for treatment of different neurodegenerative diseases as synthesized substances are toxic and can’t be used for a long time.

The purpose of research was studying of the effect polyprenol preparation derived from green needles produces in  treatment of dementias of the Alzheimer’s type along with vascular cerebral affection.
Methods. The clinical trial was conducted with 25 patients at the age of 54-78 on the bases of the Skvortsov-Stepanov Psychiatric Hospital 3. The average duration of the disease is 1,5 years. The course of treatment was 3-4 months. Polyprenols were given in a dose of 144 mg a day. Somatic therapy was used in the period of treatment. International scale of cognitive deficit MMSE, unified rating scale of Parkinson's disease, EEG data, biochemical blood values, urine analysis, activity of BCHE and monoamine oxidase (MAO). The preparation was given to the patients during 4 months. Before the treatment 12% patients had a light form of dementia, 36% — moderately marked, 32% — moderately serious, 20% — severe dementia.
 
Research results showed the effectiveness of polyprenol action on cognitive functions: 40% patients had marked improvement of cognitive functions. 48% patients had less marked effect in psychosomatic status, but a positive dynamics in the degree of manifestation of  dementia, which reduced coming from severe form to a light form.  12% patients taking polyprenols didn’t have any improvement of cognitive function.  According to EEG the condition of 80% patients improved that was shown by disappearance delta waves and paroxysms, onset of »-rhythm and disappearance of local accent in frontotemporal area. Polyprenol preparation produces normalizing effect on the activity of BCHE and monoamine oxidase (MAO) of blood serum. 25% patients had improvement of neurological status, there was 5 points reduce in Parkinson's syndrome according to parkinsonism scale in a month of treatment that is a good prognostic factor in the treatment of the disease. 
 
Conclusion. On the basis of the information received it was concluded that polyprenol preparation can be used for treatment of neurodegenerative diseases of the Alzheimer’s type. 
 
 

Back
  |  English

   Solagran Ltd.