© V. S. Soultanov 1, Y. O. Fedotova 2, V. I. Roshchin 3, T. V. Nikitina 4
1 Solagran Limited, Melbourne, Australia
2 Pavlov Institute of Physiology of Russian Academy of Sciences, Saint-Petersburg
3 Kirov Forest Technical Academy, Saint-Petersburg
4 Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences, Saint –Petersburg
Introduction. Search and development of new approaches and preparations for pharmacotherapy of dementia of different genesis including dementia of the Alzheimer's type are currently of interest. In this connection it is actual to study the use of galenic pharmaceuticals. Polyprenol preparation and Bioeffective® A are such pharmaceuticals obtained from green needles, which have natural biologically effective compounds in their composition, involved in the mechanisms of many physiological processes of the body.
The purpose of the research was studying of the effects of long-term administration of galenic pharmaceuticals – polyprenol preparation and Bioeffective® A on cognitive status of male rats on the model of dementia of the Alzheimer's type.
Methods. The experiment was conducted with Wistar male rats. Dementia model was made with male rats by surgical procedure, the trepanation of cranium and intracerebrum introduction of beta amyloid into the fourth cerebral cavity. The preparations were introduced for oral: polyprenols in a therapeutic dose of 144,0 mg/a day for human (a dose is 8,6 mg/kg), Bioeffective® A in a therapeutic dose of 960,0 mg/a day (a dose is 82,0 mg/kg). The course of treatment was 28 days. A model of conditioned passive-avoidance response and Morris water test were used for evaluation of learning processes and memory. Behaviour in the open field test was also evaluated.
Results. The results of the experiments show that the introduction of polyprenols to male rats in an experimental model of dementia completely restored a destroyed ability of animals to spatial and non-spatial types of training. As opposed to polyprenol preparation Bioeffective® A didn’t produce any positive effect on both types of training of rats under the experiment.
Conclusion. A conclusion can be made up about a possibility of clinical studying of the effect of polyprenol, derived from spruce green needles Picea abies (L.) Karst for the purpose of its further use in the therapy of cognitive abnormalities, dementia of different genesis including dementia of the Alzheimer's type. According to the findings Bioeffective® A can’t be recommended for further clinical studying in this direction. As Bioeffective® À stimulates only total motion activity of rats, restoring motor functions, it can be advised to treat motor dysfunctions and polyneuropathy of peripheric genesis.